Me personally yes, but I was a 5 and have no memory of it so I can't be of much help. I can tell you that my dad has done it a few of times from AZ and he always takes the I-10 and not the I-40.
As far as places to see/stop. Although I have no memory of my cross country trip, we did spend a summer going all over the southwest. If you are going to do the Grand Canyon and if you have time, add in Arches National Park, Four Corners (stand in four states at once - well, hands and feet), Hoover Dam, Vegas in general, Meteor Crater, if you're not absolutely terrified of heights - Royal Gorge Bridge (was the highest bridge in the world until 2001), and Joshua Tree National Park. And visit the zoo once you get to San Diego.
We're going to take the kids out west to hit the above in a couple of years once the littlest one gets old enough to remember it.
If the above is not your thing or you just want more information, there are probably hundreds of cross country travel pins on Pinterest and you could probably get some pretty good advice an itineraries on there. And before you get all nervous about Pinterest, I read a statistic that 1/3 of all new users are male. Join the 1/3 minority and plan your trip